منابع مشابه
Isolation and propagation of a virus from a spontaneous mammary carcinoma of a rhesus monkey.
Virus particles morphologically similar to the known oncogenic RNA-type viruses have been isolated and cultured from a spontaneous mammary carcinoma of a rhesus monkey. The virus was initially isolated by cocultivation of tumor tis sues with monkey embryonic cell cultures but was later found to be transmissible as a cell-free filtrate. The virus is approximately 110 m^t in diameter and has a bu...
متن کاملCryoelectron microscopy of mouse mammary tumor virus.
Cryoelectron microscopy of Mouse mammary tumor virus, a Betaretrovirus, provided information about glycoprotein structure and core formation. The virions showed the broad range of diameters typical of retroviruses. Betaretroviruses assemble cytoplasmically, so the broad size range cannot reflect the use of the plasma membrane as a platform for assembly.
متن کاملConversion of mouse mammary tumor virus to a lymphomagenic virus.
Type B leukemogenic virus is a variant of mouse mammary tumor virus (MMTV) that causes thymic lymphomas rather than mammary tumors in mice. We demonstrate that conversion of a mammotropic MMTV to a T-cell-tropic virus requires two alterations in the long terminal repeat: (i) acquisition of a T-cell-specific enhancer and (ii) loss of transcriptional repression through deletion of negative regula...
متن کاملMouse mammary tumor virus infects human cells.
Mouse mammary tumor virus (MMTV) has long been speculated to be involved in human breast cancer and more recently in human primary biliary cirrhosis. Despite complete proviral sequences markedly homologous to MMTV being identified in human breast cancer tissue, no convincing evidence has been presented to date that MMTV can infect human cells. Using both wild-type and a genetically marked virus...
متن کاملHeterogeneity of expression and induction of mouse mammary tumor virus antigens in mouse mammary tumors.
Seven spontaneous BALB/cfC3H mouse mammary tumors were heterogeneous in expression of murine mammary tumor virus-associated cell surface antigens. To determine the basis of this heterogeneity, cells from spontaneous tumors and from five subpopulations isolated from a single spontaneous tumor were examined for expression of viral antigens under both conventional conditions and conditions known t...
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ژورنال
عنوان ژورنال: Cancer
سال: 1949
ISSN: 0008-543X,1097-0142
DOI: 10.1002/1097-0142(194909)2:5<755::aid-cncr2820020503>3.0.co;2-4